Published articles

Perinatal DNA methylation at CDKN2A is associated withoffspring bone mass: Findings from the Southampton Women's Survey.

Curtis EM, Murray R, Titcombe P, Cook E, Clarke-Harris R, Costello P, Garratt E, Holbrook JD, Barton S, Inskip H, Godfrey KM, Bell CG, Cooper C, Lillycrop KA, Harvey NC.

J Bone Miner Res

2017 Apr 17. doi: 10.1002/jbmr.3153. [Epub ahead of print]



ANRIL Promoter DNA Methylation: A Perinatal Marker forLater Adiposity

Karen Lillycrop1, Robert MurrayClara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J. Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C. Burdge, Cyrus Cooper, Hazel M. InskipNeerja KarnaniJames C. HopkinsCaroline E. ChildsCarolina Paras ChavezPhilip C. CalderFabian YapYung Seng LeeYap Seng ChongPhilip E. MeltonLawrie BeilinRae-Chi HuangPeter D. GluckmanNick Harvey, Mark A. Hanson, Joanna D. Holbrook, The EpiGen Consortium, Keith M. Godfrey

EBioMedicine 2017 Apr 26. DOI: http://dx.doi.org/10.1016/j.ebiom.2017.03.037 [Epub ahead of print]

Catching diabetes

Holbrook JD.

Epigenomics 2016;8(9):1173-77 doi: 10.2217/epi-2016-0079 published Online First: Epub 2016 Sep.

PMID: 27529737


DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years.

Murray R, Bryant J, Titcombe P, Barton SJ, Inskip H, Harvey NC, Cooper C, Lillycrop K, Hanson M, Godfrey KM.

Clin Epigenetics. 2016 Sep 2;8:90. doi: 10.1186/s13148-016-0259-5. eCollection 2016.

PMID: 27594927 [PubMed - in process] Free PMC Article


The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study.

Ong YL, Quah PL, Tint MT, Aris IM, Chen LW, van Dam RM, Heppe D, Saw SM, Godfrey KM, Gluckman PD, Chong YS, Yap F, Lee YS, Foong-Fong Chong M.

Br J Nutr. 2016 Aug;116(4):621-31. doi: 10.1017/S0007114516000623. Epub 2016 Jun 24.

PMID: 27339329 [PubMed - in process]


Sexually dimorphic response to feeding mode in the growth of infants.

Cheng TS, Loy SL, Cheung YB, Chan JK, Pang WW, Godfrey KM, Gluckman PD, Kwek K, Saw SM, Chong YS, Lee YS, Lek N, Yap F.

Am J Clin Nutr. 2016 Feb;103(2):398-405. doi: 10.3945/ajcn.115.115493. Epub 2015 Dec 30.

PMID: 26718413 [PubMed - indexed for MEDLINE]


Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity.

Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Brück WM, Berger B, Brüssow H, Lee YS, Yap F, Chong YS, Godfrey KM, Holbrook JD; GUSTO Study Group.

MBio. 2015 Feb 3;6(1). pii: e02419-14. doi: 10.1128/mBio.02419-14.

PMID: 25650398 [PubMed - indexed for MEDLINE] Free PMC Article


Rate of establishing the gut microbiota in infancy has consequences for future health.

Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Brück WM, Berger B, Brüssow H, Karnani N, Lee YS, Yap F, Chong YS, Godfrey KM, Holbrook JD.

Gut Microbes. 2015;6(5):321-5. doi: 10.1080/19490976.2015.1078051. Epub 2015 Aug 20.

PMID: 26516657 [PubMed - indexed for MEDLINE] Free PMC Article


Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.Huang RC, Garratt ES, Pan H, Wu Y, Davis EA, Barton SJ, Burdge GC, Godfrey KM, Holbrook JD, Lillycrop KA.

Epigenetics. 2015;10(11):995-1005. doi: 10.1080/15592294.2015.1080411.

PMID: 26646899 [PubMed - in process] Free PMC Article


Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: results from the GUSTO study.

Chong MF, Ong YL, Calder PC, Colega M, Wong JX, Tan CS, Lim AL, Fisk HL, Cai S, Pang WW, Broekman BF, Saw SM, Kwek K, Godfrey KM, Chong YS, Gluckman P, Meaney MJ, Chen H; GUSTO Study Group.

J Clin Psychiatry. 2015 Jul;76(7):e848-56. doi: 10.4088/JCP.14m09191.

PMID: 26231011 [PubMed - indexed for MEDLINE]


HIF3A association with adiposity: the story begins before birth.

Pan H, Lin X, Wu Y, Chen L, Teh AL, Soh SE, Lee YS, Tint MT, MacIsaac JL, Morin AM, Tan KH, Yap F, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Gluckman PD, Karnani N, Holbrook JD; GUSTO Study Group.

Epigenomics. 2015;7(6):937-50. doi: 10.2217/epi.15.45. Epub 2015 May 26.

PMID: 26011824 [PubMed - indexed for MEDLINE] Free PMC Article


Maternal Protein Intake during Pregnancy Is Not Associated with Offspring Birth Weight in a Multiethnic Asian Population.

Chong MF, Chia AR, Colega M, Tint MT, Aris IM, Chong YS, Gluckman P, Godfrey KM, Kwek K, Saw SM, Yap F, van Dam RM, Lee YS; GUSTO Study Group.

J Nutr. 2015 Jun;145(6):1303-10. doi: 10.3945/jn.114.205948. Epub 2015 May 6.

PMID: 25948786 [PubMed - indexed for MEDLINE] Free Article


Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.

Lillycrop KA, Costello PM, Teh AL, Murray RJ, Clarke-Harris R, Barton SJ, Garratt ES, Ngo S, Sheppard AM, Wong J, Dogra S, Burdge GC, Cooper C, Inskip HM, Gale CR, Gluckman PD, Harvey NC, Chong YS, Yap F, Meaney MJ, Rifkin-Graboi A, Holbrook JD; Epigen Global Research Consortium, Godfrey KM.

Int J Epidemiol. 2015 Aug;44(4):1263-76. doi: 10.1093/ije/dyv052. Epub 2015 Apr 22.

PMID: 25906782 [PubMed - indexed for MEDLINE] Free PMC Article


Relations of plasma polyunsaturated Fatty acids with blood pressures during the 26th and 28th week of gestation in women of Chinese, Malay, and Indian ethnicity.

Lim WY, Chong M, Calder PC, Kwek K, Chong YS, Gluckman PD, Godfrey KM, Saw SM, Pan A; GUSTO Study Group.

Medicine (Baltimore). 2015 Mar;94(9):e571. doi: 10.1097/MD.0000000000000571.

PMID: 25738474 [PubMed - indexed for MEDLINE] Free PMC Article


Maternal folate status, but not that of vitamins B-12 or B-6, is associated with gestational age and preterm birth risk in a multiethnic Asian population.

Chen LW, Lim AL, Colega M, Tint MT, Aris IM, Tan CS, Chong YS, Gluckman PD, Godfrey KM, Kwek K, Saw SM, Yap F, Lee YS, Chong MF, van Dam RM.

J Nutr. 2015 Jan;145(1):113-20. doi: 10.3945/jn.114.196352. Epub 2014 Nov 12.

PMID: 25527665 [PubMed - indexed for MEDLINE] Free Article


The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.

Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stünkel W, Kobor MS, Meaney MJ, Gluckman PD, Holbrook JD.

Genome Res. 2014 Jul;24(7):1064-74. doi: 10.1101/gr.171439.113. Epub 2014 Apr 7.

PMID: 24709820 [PubMed - indexed for MEDLINE] Free PMC Article


Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study.

Chong MF, Wong JX, Colega M, Chen LW, van Dam RM, Tan CS, Lim AL, Cai S, Broekman BF, Lee YS, Saw SM, Kwek K, Godfrey KM, Chong YS, Gluckman P, Meaney MJ, Chen H; GUSTO study group.

J Psychiatr Res. 2014 Aug;55:110-6. doi: 10.1016/j.jpsychires.2014.04.006. Epub 2014 Apr 16.

PMID: 24774647 [PubMed - indexed for MEDLINE]


Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.

Harvey NC, Sheppard A, Godfrey KM, McLean C, Garratt E, Ntani G, Davies L, Murray R, Inskip HM, Gluckman PD, Hanson MA, Lillycrop KA, Cooper C.

J Bone Miner Res. 2014 Mar;29(3):600-7. doi: 10.1002/jbmr.2056.

PMID: 23907847 [PubMed - indexed for MEDLINE] Free PMC Article


Non-imprinted epigenetics in fetal and postnatal development and growth.

Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA.

Nestle Nutr Inst Workshop Ser. 2013;71:57-63. doi: 10.1159/000342552. Epub 2013 Jan 22.

PMID: 23502139 [PubMed - indexed for MEDLINE]


Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content.

Harvey NC, Lillycrop KA, Garratt E, Sheppard A, McLean C, Burdge G, Slater-Jefferies J, Rodford J, Crozier S, Inskip H, Emerald BS, Gale CR, Hanson M, Gluckman P, Godfrey K, Cooper C.

Calcif Tissue Int. 2012 Feb;90(2):120-7. doi: 10.1007/s00223-011-9554-5. Epub 2011 Dec 8.

PMID: 22159788 [PubMed - indexed for MEDLINE] Free PMC Article


Epigenetic gene promoter methylation at birth is associated with child's later adiposity.

Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR, Emerald BS, Gale CR, Inskip HM, Cooper C, Hanson MA.

Diabetes. 2011 May;60(5):1528-34. doi: 10.2337/db10-0979. Epub 2011 Apr 6.

PMID: 21471513 [PubMed - indexed for MEDLINE] Free PMC Article


Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms.

Hanson M, Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD.

Prog Biophys Mol Biol. 2011 Jul;106(1):272-80. doi: 10.1016/j.pbiomolbio.2010.12.008. Epub 2011 Jan 8. Review.

PMID: 21219925 [PubMed - indexed for MEDLINE]


Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats.

Lillycrop KA, Rodford J, Garratt ES, Slater-Jefferies JL, Godfrey KM, Gluckman PD, Hanson MA, Burdge GC.

Br J Nutr. 2010 Jun;103(12):1711-9. doi: 10.1017/S0007114509993795. Epub 2010 Mar 9.

PMID: 20211039 [PubMed - indexed for MEDLINE]


Developmental origins of metabolic disease: life course and intergenerational perspectives.

Trends Endocrinol Metab. 2010 Apr;21(4):199-205. doi: 10.1016/j.tem.2009.12.008. Epub 2010 Jan 14. Review.

PMID: 20080045 [PubMed - indexed for MEDLINE]


Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease.

Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA.

Pediatr Res. 2007 May;61(5 Pt 2):5R-10R. Review.

PMID: 17413851 [PubMed - indexed for MEDLINE]